Once-daily DosingTreat HIV

Features of LEXIVA

LEXIVA can be a key part of HIV treatment

LEXIVA has many benefits when taken with other medicines for HIV. If you have not taken protease inhibitors before, and are starting therapy with LEXIVA plus ritonavir, you may be able to:

  • Enjoy the convenience of eating and drinking whenever you want; LEXIVA can be taken with or without food
  • Take LEXIVA once-a-day with ritonavir, if your healthcare provider recommends it
  • Use common antacids or heartburn medications without worrying about changing how LEXIVA works*
  • Be less likely to have serious diarrhea as a side effect
  • Take less ritonavir per day (100 mg) if your healthcare provider recommends it

HIV resistance

If HIV becomes resistant to a certain medicine, it means that the virus has changed itself in such a way that the medicine is no longer useful in fighting it. When this happens, you might need to switch medicines altogether, and this can limit your treatment options.

This kind of resistance did not happen during a study of people taking LEXIVA with ritonavir over 120 weeks.

Next: Learn more about taking LEXIVA with ritonavir.

* LEXIVA without ritonavir may be less effective because of decreased amprenavir plasma concentrations in patients taking H2-receptor antagonists concomitantly. No dose adjustment required with proton pump inhibitors when administered at at the same time as LEXIVA.

In a study versus nelfinavir serious diarrhea was experienced by 1 in 10 patients taking LEXIVA versus 2 in 10 patients taking nelfinavir.

See the full Prescribing Information for LEXIVA

LEXIVA® (fosamprenavir calcium)

Indication and Usage:

LEXIVA treats HIV infection in adults. It should always be used in combination with other HIV medicines. These medicines do not cure HIV infection/AIDS or prevent passing HIV to others.

Important Safety Information

  • You should not take LEXIVA if you have had an allergic reaction to LEXIVA or AGENERASE® (amprenavir)
  • High blood sugar, diabetes or worsening of diabetes, and bleeding in hemophiliacs have occurred in some patients taking protease inhibitors
  • When you start taking HIV medicines, your immune system may get stronger and could begin to fight infections that have been hidden in your body, such as pneumonia, herpes virus, or tuberculosis. If you have new symptoms after starting your HIV medicines, be sure to tell your doctor
  • Changes in body fat may occur in some patients taking antiretroviral therapy. The cause and long-term health effects of these conditions are not known at this time
  • Skin rashes can occur in patients taking LEXIVA. Rarely, rashes were severe or life threatening
  • Opportunistic infections can develop when you have HIV and your immune system is weak. It is very important that you see your healthcare provider regularly while you are taking LEXIVA to discuss any side effects or concerns
  • Most common side effects in clinical studies were diarrhea, headache, nausea, rash, and vomiting. In most cases, these side effects did not cause people to stop taking their medicine

DRUG INTERACTIONS

  • LEXIVA should not be taken with: AGENERASE® (amprenavir), Halcion® (triazolam), ergot medications (Cafergot®, Migranal®, D.H.E. 45®, and others), Propulsid® (cisapride), Versed® (midazolam), Orap® (pimozide), Zocor® (simvastatin), Mevacor® (lovastatin), Rifadin® (rifampin), Rescriptor® (delavirdine mesylate), or St. John's wort (Hypericum perforatum). If you are taking Norvir® (ritonavir), you should not take Tambocor® (flecainide), or Rythmol® (propafenone hydrochloride)
  • Serious and/or life-threatening events could occur between LEXIVA and other medications, including Cordarone® (amiodarone), lidocaine (intravenous only), Elavil® (amitriptyline HCl) and Tofranil® (imipramine pamoate), tricyclic antidepressants, and Quinaglute® (quinidine)
  • Women who use birth control should choose a different kind of contraception. LEXIVA can affect the safety and effectiveness of birth control pills.
  • Patients taking Viagra® (sildenafil citrate) or LEVITRA® (vardenafil HCl) with LEXIVA may be at an increased risk of side effects
  • This list of drug interactions is not complete. Be sure to tell your healthcare provider about all medicines you are taking or plan to take, including over-the-counter drugs, vitamins, and herbals
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